The Harvard Aging Brain Study (HABS) is a longitudinal cohort aimed at detecting early imaging markers of cognitive decline and preclinical Alzheimer’s disease among older adults.
Official Website: habs.mgh.harvard.edu
Data Status: Processing all imaging data is underway and scheduled.
The Clarity in ADRD Research Through Imaging (CLARiTI) is a consortium initiative aiming to standardize imaging and plasma biomarker data across ADRCs to enhance Alzheimer’s and related dementias (ADRD) research.
Official Website: clariti.naccdata.org
Data Status: Processing all imaging data is underway and scheduled.
The Strategic Research Program for Brain Sciences (SRPBS) is Japan’s nationwide initiative supporting brain science research, including large-scale imaging and psychiatric disorder studies under AMED’s strategy.
Official Website: amed.go.jp
Data Status: Processing all imaging data is underway and scheduled.
The Chinese Color Nest Project (CCNP) is an accelerated longitudinal study in China (2013–2022), modeling normative brain developmental trajectories across the human lifespan (ages ~6–85 years) using behavioral and MRI data.
Official Website: scidb.cn/en/c/ccnp
Data Status: Processing all imaging data is underway and scheduled.
The Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset is a longitudinal, multi-center study designed to develop clinical, imaging, genetic, and biochemical biomarkers for the early detection and tracking of Alzheimer's Disease (AD).
Official Website: adni.loni.usc.edu
Below, we summarize the modalities and number of subjects processed and available for request in Mind Data Hub:
Preprocessing Steps:
Data Available:
Metadata:
Comprehensive demographic, clinical, and scanner metadata, QC scores based on SynthSeg.
Metadata Source Files:
Processed data are organized in a CSV file with the following columns:
| Column Name | Description |
|---|---|
| subjectId | Subject identifier (XXX_S_XXXX format) |
| sessionName | Session date (YYYY-MM-DD format) |
| MNI_Warped | Path to MNI warped brain file |
| MNI_ZSCORE | Path to z-score normalized file |
| MNI_Z_Cropped | Path to cropped z-score file |
| age | Age in years (range: 51-104, mean: ~73.8) |
| sex | Sex encoded (1=male, 2=female) |
| handedness | Handedness (0=unknown, 1=right, 2=left, 3=ambidextrous) |
| ethnicity | Ethnicity (0=unknown, 1=non-hispanic, 2=hispanic) |
| race | Race (standardized 0-7 encoding) |
| education | Education level in years |
| marital_status | Marital status (1-6 encoding) |
| work_status | Work status (1=no, 2=yes, 0=unknown) |
| home_status | Home living situation (1-10 encoding) |
| research_group | Research classification (CN, EMCI, LMCI, MCI, AD, SMC, Patient) |
| scanner_manufacturer | Scanner brand (GE, Siemens, Philips, etc.) |
| overall_qc_score | SynthSeg quality score (0-1 scale, higher=better) |
Encoding Dictionaries:
Note: Due to the high volume of T1 scans per subject, the best-quality scan per subject/session was selected based on ADNI QC recommendations. Also, if a subject has more than one scan in the same session, we ranked them considering SynthSeg.
Download Data Date: February 2025
Preprocessing Steps (fMRIPrep):
Data Available:
Dedicated scripts are available for both BIDS conversion and parcellation:
Download Data Date: February 2025
Preprocessing Steps:
Data Available:
DTI scans: All Adni 1, 2,Go, 3 and 4 DTI scans, and Metadata.
Download Data Date: July 2025
To request access to ADNI data, please fill out our internal request form. Requests will be reviewed by our data management team.
When using ADNI data, please cite the official ADNI project and acknowledge the Mind Data Hub preprocessing pipeline:
“Data used in the preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). The preprocessing and harmonization of data were performed by Mind Data Hub at Stanford University.”
The Nathan Kline Institute Rockland Sample (NKI) is a large-scale biobank from the Child Mind Institute, collecting neuroimaging and behavioral data from over 10,000 children and adolescents (ages 5–21), including MRI, EEG, eye-tracking, voice/video, genetics, and actigraphy.
Official Website: rocklandsample.org
Data Status: Processing all imaging data is underway and scheduled.
The Healthy Brain Network (HBN) is a large-scale biobank from the Child Mind Institute, collecting neuroimaging and behavioral data from over 10,000 children and adolescents (ages 5–21), including MRI, EEG, eye-tracking, voice/video, genetics, and actigraphy.
Official Website: data.healthybrainnetwork.org/main.php
Data Status: Processing all imaging data is underway and scheduled.
The Philadelphia Neurodevelopmental Cohort (PNC) includes neuroimaging, rich cognitive, clinical phenotyping, and genomics data from youth (ages 8–21) from the greater Philadelphia area, representing nearly 9,500 individuals.
Official Website: med.upenn.edu/bbl/philadelphianeurodevelopmentalcohort.html
Data Status: Processing all imaging data is underway and scheduled.
The OASIS – Open Access Series of Imaging Studies project provides freely accessible neuroimaging datasets spanning healthy aging and Alzheimer’s disease. It includes multiple sub-datasets: OASIS‑1 (cross-sectional), OASIS‑2 (longitudinal), OASIS‑3 (multimodal: MRI, PET, clinical, biomarkers), and OASIS‑4 (clinical memory-impaired cohort)
Official Website: sites.wustl.edu/oasisbrain
Data Status: Processing all imaging data is underway and scheduled.
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